×

UPSC Courses

DNA banner

DAILY NEWS ANALYSIS

GS-III :
  • 19 July, 2020

  • 5 Min Read

Covid-19 Vaccine: ZyCoV-D

Covid-19 Vaccine: ZyCoV-D

GS-PAPER-3 S&T

Recently, India has started phase I/II clinical trials of Covid-19 vaccine - ZyCoV-D, designed and developed by Zydus (a pharmaceutical company) with support from the Department of Biotechnology (DBT).

The adaptive phase I/II clinical trials will assess the safety, tolerability and immunogenicity of the vaccine. The other indigenously developed vaccine - Covaxin - produced by Hyderabad based Bharat Biotech is also underway to start clinical trials.

Imp Points

  • Description: ZyCoV-D, a plasmid DNA vaccine, comes under the Vaccine Discovery Programme supported by the Department of Biotechnology under the National Biopharma Mission.

National Biopharma Mission

  • It is an industry-academia collaborative mission for accelerating biopharmaceutical development in the country.
  • It was launched in 2017 at a total cost of Rs. 1500 crore and is 50% co-funded by World Bank loan.
  • It is being implemented by the Biotechnology Industry Research Assistance Council (BIRAC).

(BIRAC is a Public Sector Enterprise, set up by the Department of Biotechnology (DBT), Ministry of Science & Technology)

  • Under this Mission, the Government has launched Innovate in India (i3) programme to create an enabling ecosystem to promote entrepreneurship and indigenous manufacturing in the biopharma sector.
  • Objectives: Development of vaccines, medical devices, diagnostics and biotherapeutics besides, strengthening the clinical trial capacity and building technology transfer capabilities in the country.

Plasmids are circular deoxyribonucleic acid (DNA) vectors that can be used as vaccines to prevent various types of diseases.

  • Pre-Clinical Phase: It was found to initiate a strong immune response in multiple animal species like mice, rats, guinea pigs and rabbits.
    • The antibodies produced by the vaccine were able to neutralize the wild type virus indicating the protective potential of the vaccine candidate.
    • No safety concerns were observed in repeat dose by both intramuscular (directly into muscles)
    • intradermal (superficial injection into skin) routes of administration.
  • DNA Vaccine Platform: The development of ZyCov-D has established the DNA vaccine platform in the country which is simple to deploy, temperature stable, and consistently manufacturable- thus lowering costs and enhancing the effectiveness of a vaccine.

It provides ease of manufacturing the vaccine with minimal biosafety requirements. It has shown much improved vaccine stability and lower cold chain requirements making it easy for transportation to remote regions of the country. Furthermore, the platform can be rapidly used to modify the vaccine in a couple of weeks in case the virus mutates.

Source: IE


Operation 'Megha Chakra' on Child Sexual Abuse

Operation 'Megha Chakra' on Child Sexual Abuse The "Megh Chakra" operation is being carried out in response to inputs from Interpol's Singapore special unit based on the information obtained from the New Zealand authorities. The Central Bureau of Investigation (CBI) is waging a nationwide campaign against the dissemina

World Tourism Day and India’s status

World Tourism Day and India’s status Every year on September 27, people all over the world celebrate World Tourism Day. This year, it will take place in Bali, Indonesia. “Rethinking Tourism” is the theme for 2022. ??????? What are the Main Ideas? Since 1980, September 27 has been observed as World Tourism Day

Jaldoot App & Groundwater Status in India

Jaldoot App & Groundwater Status in India The "JALDOOT App and JALDOOT App e-brochure" was recently released by the Ministry of Rural Development to better measure groundwater levels. ??????? About JALDOOT app  The Panchayati Raj and the Ministry of Rural Development collaborated to create the JALDOOT app.

Group of Four (G4) on UNSC Reform

Group of Four (G4) on UNSC Reform Under the auspices of The Group of Four (G4), the External Affairs Minister of India met with his counterparts from Brazil, Germany, and Japan. Details about the news G4 discussed concerns pertaining to the UN Security Council reform during a meeting that took place alongside the 77th session of the

Draft Indian Telecommunication Bill 2022

Draft Indian Telecommunication Bill 2022 To control Internet-based OTT (Over-The-Top) telecom services, the Department of Telecommunications (DoT) recently announced the draught Indian Telecommunications 2022 Bill. ?????????????? What are the Draft Bill's Main Points? The Indian Telegraph Act, 1885, Indian Wireless Telegraph

Toppers

Search By Date

Newsletter Subscription
SMS Alerts