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DAILY NEWS ANALYSIS

Monthly DNA

24 Apr, 2026

78 Min Read

Paper Topics Subject
GS-III Neuralink’s ‘Blindsight’ Chip
PT Pointer Alaknanda Galaxy S&T Developments & their Applications & Effects in Everyday Life
Naval Communication Satellite CMS-03 Indigenization of Technology & Developing New Technology
India to Establish Two New Telescopes in Ladakh S&T Developments & their Applications & Effects in Everyday Life
BSL-4 Containment Facility in Gandhinagar S&T Developments & their Applications & Effects in Everyday Life
GlowCas9: A CRISPR Protein that lights up Gene Editing S&T Developments & their Applications & Effects in Everyday Life
Brain-Computer Interface to Restore Natural Speech S&T Developments & their Applications & Effects in Everyday Life
“Transneuron” S&T Developments & their Applications & Effects in Everyday Life
Miniature TnpB-based Genome Editing Tool S&T Developments & their Applications & Effects in Everyday Life
Antibiotic-Producing Thermophilic Bacteria S&T Developments & their Applications & Effects in Everyday Life
World’s First Genome-Edited Rice Varieties S&T Developments & their Applications & Effects in Everyday Life
Scientists Discover Key to Delaying Female Fertility Decline S&T Developments & their Applications & Effects in Everyday Life
India’s First Polar Research Vessel S&T Developments & their Applications & Effects in Everyday Life
Maitri II: India’s Upcoming Antarctic Research Station S&T Developments & their Applications & Effects in Everyday Life
Wet Tests of Matsya-6000 S&T Developments & their Applications & Effects in Everyday Life
Skin Diseases: A Global Public Health Priority S&T Developments & their Applications & Effects in Everyday Life
WHO Declares Hepatitis D as Carcinogenic S&T Developments & their Applications & Effects in Everyday Life
New Drug Candidate to Tackle Deadly Superbugs S&T Developments & their Applications & Effects in Everyday Life
9th Asian Winter Games World Sports
Neuralink’s ‘Blindsight’ Chip

GS-III :

Neuralink’s ‘Blindsight’ Chip

Recently, Elon Musk announced that his neurotechnology company Neuralink plans to implant its artificial visual prosthesis, Blindsight, in a human for the first time.

The experimental device aims to partially restore vision in blind individuals through a brain chip embedded in the visual cortex.

Key Features of Blindsight
Feature Details
Device Type An artificial visual prosthesis designed to restore partial vision through direct brain stimulation.
Implant Location The chip is implanted in the visual cortex, the brain region responsible for processing visual information.
FDA Status Blindsight received the US FDA’s breakthrough device status in September 2024, allowing faster development and review.
Working Mechanism It uses a microelectrode array to stimulate neurons in the visual cortex based on inputs from an external camera.
Initial Vision Quality Initial versions are expected to provide low-resolution vision, comparable to early Atari-style graphics.
Target Beneficiaries It aims to help individuals who have lost both eyes and optic nerves, and possibly those blind from birth.
Scientific Importance
  • Represents a major development in brain-machine interface technology.
  • Shows how neural prosthetics can bypass damaged eyes and optic nerves.
  • May help restore partial sensory function through direct brain stimulation.
  • Could support future advances in assistive neurotechnology and visual rehabilitation.
PT Facts
  • Visual Cortex: Brain region responsible for processing visual information.
  • Microelectrode Array: Can stimulate or record electrical signals from neurons.
  • FDA Breakthrough Device: Status given to devices that may offer more effective treatment for serious conditions.
  • Neural Prosthetics: Part of the wider field of brain-machine interfaces.

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Alaknanda Galaxy

GS-III : S&T Developments & their Applications & Effects in Everyday Life Space Technology

Alaknanda Galaxy

Indian astronomers analysing data from the James Webb Space Telescope (JWST) identified a massive spiral galaxy named Alaknanda, dating back to a time when the Universe was only about 1.5 billion years old.

The galaxy appears remarkably similar to the Milky Way, despite forming when the cosmos was only around 10% of its present age.

What Makes This Discovery Unusual?
Aspect Details
Earlier Understanding Early galaxies were generally believed to be small, chaotic, and irregular during the period known as the “cosmic dawn”.
Structure of Alaknanda The galaxy displays two symmetrical spiral arms, a bright central bulge, and an organised galactic disk.
Scientific Importance The discovery suggests that large, structured spiral galaxies may have formed much earlier than previously believed.
Why the Discovery Matters
  • Challenges conventional theories about galaxy formation in the early universe.
  • Provides insights into the rapid evolution of cosmic structures after the Big Bang.
  • Demonstrates the advanced observational capabilities of the James Webb Space Telescope.
  • Improves understanding of the Milky Way’s possible evolutionary history.
PT Facts
  • James Webb Space Telescope: An infrared space telescope used to study early galaxies, exoplanets, and star formation.
  • Galaxy Formation: The discovery challenges earlier assumptions about how quickly large spiral galaxies formed after the Big Bang.
  • Infrared Astronomy: Useful for studying distant galaxies because their light becomes redshifted over time.
  • Cosmic Dawn: Refers to the early phase of the universe after the Big Bang when the first galaxies formed.

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Naval Communication Satellite CMS-03

GS-III : Indigenization of Technology & Developing New Technology Space - ISRO

Naval Communication Satellite CMS-03

On 2nd November 2025, the Indian Space Research Organisation (ISRO) successfully launched CMS-03, an advanced military communication satellite, aboard the LVM3-M5 rocket from Sriharikota.

The mission marked a major enhancement in India’s maritime communication capabilities and strategic self-reliance in defence space infrastructure.

Feature Details
Satellite Type Dedicated naval communication satellite belonging to the GSAT-7R class.
Launch Vehicle Launched aboard the LVM3 rocket into Geosynchronous Transfer Orbit (GTO).
Launch Mass Weighing 4,400 kg, it became ISRO’s heaviest communication satellite launched from Indian soil.
Primary User Developed primarily for the Indian Navy.
Coverage Area Covers the Indian subcontinent and a vast portion of the Indian Ocean Region (IOR).
Orbit Positioned in Geosynchronous Orbit after orbit raising using the Liquid Apogee Motor (LAM).
Key Capabilities Provides secure voice, data, and video communication links along with support for network-centric warfare operations.
Strategic Importance
  • Strengthens India’s maritime surveillance and communication network.
  • Enhances secure naval connectivity across the Indian Ocean Region.
  • Supports real-time information sharing and network-centric naval operations.
  • Boosts India’s indigenous strategic communication infrastructure.
PT Facts
  • CMS-03: Significant for India’s maritime security and naval communication capability.
  • Geosynchronous Orbit: Satellites match Earth’s rotation period and are ideal for communication services.
  • Indian Ocean Region: Central to India’s maritime strategy and sea-lane security interests.
  • LAM: Liquid Apogee Motors are used for orbit raising and satellite positioning.

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India to Establish Two New Telescopes in Ladakh

GS-III : S&T Developments & their Applications & Effects in Everyday Life Space Technology

India to Establish Two New Telescopes in Ladakh

In the Union Budget 2026–27, the Government of India approved a major expansion of ground-based astronomy infrastructure in Ladakh.

The programme includes the establishment of two new mega-telescopes and the upgradation of the existing Himalayan Chandra Telescope (HCT).

Major Telescope Projects
Telescope / Facility Details
National Large Solar Telescope (NLST) A high-resolution solar telescope near Pangong Tso Lake, Ladakh, designed to study the Sun’s surface and atmosphere. It will complement the Kodaikanal Solar Observatory, Udaipur Solar Observatory, and the Aditya-L1 mission.
National Large Optical–Near Infrared Telescope (NLOT) A deep-space optical and near-infrared telescope intended for advanced cosmic research and astronomical observations.
Scientific Applications Research areas include exoplanets, stellar and galactic evolution, cosmology, supernovae, and distant galaxies.
Himalayan Chandra Telescope Upgrade The HCT will be upgraded with a 3.7-metre segmented primary mirror, improving sensitivity and extending wavelength coverage into optical-infrared regimes.
Scientific Impact The upgraded HCT will enable deeper observations and complement both international observatories and the new Indian telescopes.
Why Ladakh is Ideal for Astronomy
  • High altitude and thin atmosphere improve astronomical visibility.
  • Dry climate and low atmospheric water vapour reduce signal distortion.
  • Dark skies with minimal light pollution support deep-space observations.
  • Cold desert conditions make Ladakh suitable for infrared astronomy.
PT Facts
  • Ladakh Advantage: High altitude, dry climate, low atmospheric water vapour, and dark skies make it ideal for astronomy.
  • Near-Infrared Telescopes: Useful for studying cool stars, dust-obscured regions, and distant galaxies.
  • Aditya-L1: India’s solar observatory studying the Sun from the L1 point in the Sun-Earth system.
  • Solar Telescopes: Help study sunspots, solar flares, coronal mass ejections, and space weather.

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BSL-4 Containment Facility in Gandhinagar

GS-III : S&T Developments & their Applications & Effects in Everyday Life Bio-Technology

BSL-4 Containment Facility in Gandhinagar

On 13th January 2026, the Union Home Minister laid the foundation stone of a Bio-Safety Level-4 (BSL-4) Containment Facility and laboratory in Gandhinagar, Gujarat.

This is only the second civilian BSL-4 laboratory in India after the National Institute of Virology (NIV), Pune.

In late 2024, DRDO established a dedicated defence-sector BSL-4 facility in Gwalior, Madhya Pradesh.

What is a BSL-4 Facility?
Aspect Details
Containment Level BSL-4 is the highest level of biological containment.
Pathogen Category Designed for research on extremely dangerous and highly infectious pathogens that often lack effective vaccines or treatments.
Major Uses Used for diagnostics, vaccine and therapeutic development, and rapid outbreak response.
About the Gandhinagar BSL-4 Facility
Feature Details
Facility Status First fully state-funded and state-controlled BSL-4 facility.
Implementing Body Implemented by the Gujarat State Biotechnology Mission.
Operational Institution Operational under the Gujarat Biotechnology Research Centre (GBRC).
Lab Components Includes BSL-4, BSL-3, BSL-2, and Animal BSL-4 (ABSL-4) laboratories.
National Facility Status Declared a national facility through an MoU with the Department of Biotechnology (DBT).
PT Facts
  • BSL-4 Labs: Handle the most dangerous biological agents requiring maximum containment.
  • NIV Pune: Major Indian institute for virology, outbreak investigation, and pathogen research.
  • DBT: Department of Biotechnology under the Ministry of Science and Technology.
  • ABSL-4: Used for animal studies involving high-risk pathogens.

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GlowCas9: A CRISPR Protein that lights up Gene Editing

GS-III : S&T Developments & their Applications & Effects in Everyday Life Bio-Technology

GlowCas9: A CRISPR Protein that Lights Up Gene Editing

In December 2025, scientists at the Bose Institute, Kolkata developed GlowCas9, a novel CRISPR protein capable of emitting light while carrying out gene editing.

The innovation introduces a new method to directly visualise genome editing activity in real time.

What Makes GlowCas9 Special?
Feature Details
Real-time Visualisation GlowCas9 allows scientists to visualise genome editing activity while it is occurring inside living cells.
Bioluminescent Cas9 It is a bioluminescent version of Cas9 created by fusing Cas9 with a split nano-luciferase enzyme derived from deep-sea shrimp proteins.
Light-emitting Mechanism When Cas9 folds correctly inside a cell, the enzyme fragments rejoin and emit light resembling a gentle firefly glow.
Scientific Advantage Enables tracking of CRISPR activity in living cells, tissues, and plant leaves without destroying the samples.
Scientific Importance
  • Improves monitoring of gene-editing efficiency in real time.
  • Reduces the need to destroy biological samples during analysis.
  • Can support advances in medical biotechnology, crop science, and genetic research.
  • Enhances precision and transparency in CRISPR-based applications.
PT Facts
  • CRISPR-Cas9: A gene-editing tool adapted from a bacterial defence mechanism.
  • Cas9: Functions like a molecular scissor that cuts DNA at a targeted location.
  • Bioluminescence: Light produced naturally by living organisms or biological reactions.
  • GlowCas9: Helps track gene-editing activity in real time without destroying samples.

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Brain-Computer Interface to Restore Natural Speech

GS-III : S&T Developments & their Applications & Effects in Everyday Life Bio-Technology

Brain-Computer Interface to Restore Natural Speech

Researchers recently developed a breakthrough Brain-Computer Interface (BCI) capable of restoring naturalistic speech for individuals suffering from severe paralysis.

The system converts brain activity directly into audible speech in near real time, marking a major advancement in assistive neurotechnology.

Key Features of the BCI System
Feature Details
AI-driven Translation The BCI uses artificial intelligence to instantly translate brain signals into audible speech with near-synchronous voice streaming.
Neural Signal Source The system samples neural activity from the motor cortex, the brain region controlling speech-related movements.
AI Speech Processing Functions similarly to voice assistants such as Alexa and Siri by decoding speech-related neural patterns.
Personalised Voice Output The AI model was trained to reproduce Ann’s pre-injury voice, making communication more natural and personalised.
Reduced Delay Earlier BCI systems required nearly 8 seconds to generate speech, while the new system works in near real time.
Medical Relevance The technology can assist people affected by ALS, stroke-induced paralysis, and severe motor disabilities.
Why This Technology Matters
  • Restores communication ability for people with severe paralysis.
  • Improves quality of life through personalised speech generation.
  • Advances the field of assistive neurotechnology and AI-human interaction.
  • Demonstrates the growing role of artificial intelligence in healthcare applications.
PT Facts
  • BCI: Brain-Computer Interface creates a direct communication pathway between the brain and an external device.
  • Motor Cortex: Involved in planning and controlling voluntary movements, including speech-related actions.
  • BCI Applications: Useful for paralysis, speech loss, neurodegenerative disorders, and severe motor disabilities.
  • Assistive Neurotechnology: Combines neuroscience, AI, and computing to support impaired human functions.

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“Transneuron”

GS-III : S&T Developments & their Applications & Effects in Everyday Life Bio-Technology

“Transneuron”

Recently, researchers developed a single artificial neuron called a “transneuron”, capable of replicating activity associated with multiple regions of the human brain.

The breakthrough is considered a significant step toward machines with more human-like sensing, adaptability, and computational behaviour.

What is a Transneuron?
Feature Details
Multi-functional Capability The transneuron can switch between motor, pre-motor, and visual functions.
Difference from Conventional Artificial Neurons Unlike traditional artificial neurons that perform a single task, transneurons can adapt to multiple neural functions.
Information Processing Processes information using electrical pulses in a manner similar to biological neurons.
Scientific Importance
  • Brings machines closer to adaptive and brain-like computational behaviour.
  • May improve multifunctional AI systems capable of flexible responses.
  • Can support advancements in robotics, neuromorphic computing, and intelligent sensing systems.
  • Represents progress toward next-generation artificial intelligence inspired by biological neural networks.
PT Facts
  • Artificial Neurons: Computational models inspired by biological neurons.
  • Adaptive AI: Transneurons may improve AI systems through multifunctional neural behaviour.
  • Neuromorphic Computing: Linked with robotics and next-generation artificial intelligence.
  • Neuromorphic Systems: Aim to mimic the structure and functioning of the human brain.

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Miniature TnpB-based Genome Editing Tool

GS-III : S&T Developments & their Applications & Effects in Everyday Life Bio-Technology

Miniature TnpB-based Genome Editing Tool

Recently, Indian researchers created a hypercompact genome-editing system using TnpB proteins, offering a homegrown alternative to proprietary CRISPR-Cas technologies.

What is the TnpB-based Genome Editing System?
Aspect Details
Nature of TnpB TnpB is a tiny, next-generation genome-editing enzyme that works like CRISPR but is far more compact.
Working Mechanism It functions as a molecular scissor, cutting plant DNA at a precise target location guided by a matching RNA sequence.
Key Features and Advantages
Feature Explanation
Hypercompact Size TnpB has only 400–500 amino acids, compared with 1,000–1,400 in Cas9 and around 1,300 in Cas12a.
Easy Delivery Its small size enables viral vector delivery directly into plant cells, reducing dependence on laborious tissue-culture-based transfer.
Indigenous & IP-Free Since the system is patented by ICAR, Indian breeders can use it without paying licensing fees to foreign CRISPR patent holders.
Next-Generation Editing Enables precise editing of genes already present within the plant, without introducing foreign DNA.
Efficient Gene Targeting Uses guide RNA to navigate to the exact DNA address and modify genes linked with yield, drought tolerance, and disease resistance.
BACILLUS SUBTILIS: STATE MICROBE OF KERALA
  • Kerala has become the first Indian state to declare Bacillus subtilis as its official State Microbe.
  • Bacillus subtilis is a beneficial probiotic bacterium commonly found in soil, fermented foods, and the human gut.
  • It is widely studied for improving gut health, boosting immunity, enhancing soil fertility, and controlling plant diseases.
PT Facts
  • TnpB: Smaller than Cas9, making it easier to deliver into cells.
  • ICAR: Stands for Indian Council of Agricultural Research.
  • Genome Editing: Editing without foreign DNA helps develop improved crops with fewer regulatory concerns.
  • Bacillus subtilis: Beneficial in agriculture, probiotics, and biotechnology.

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Antibiotic-Producing Thermophilic Bacteria

GS-III : S&T Developments & their Applications & Effects in Everyday Life Bio-Technology

Antibiotic-Producing Thermophilic Bacteria

In a new breakthrough, researchers discovered thermophilic bacteria with strong antibiotic potential in the Rajgir hot spring located in Nalanda, Bihar.

What are Thermophiles?
Aspect Details
Nature Thermophiles are heat-loving bacteria that thrive at temperatures between 45°–70°C.
Habitat Commonly found in hot springs, thermal vents, compost piles, and even microwave ovens.
Antibiotic Potential Some thermophiles produce powerful antibiotics to survive in low-competition, mineral-rich environments.
PT Facts
  • Thermophiles: Extremophiles that grow at high temperatures.
  • Hot Springs: Important sites for discovering heat-stable enzymes and novel microbes.
  • Antimicrobial Resistance: New antibiotic-producing microbes are important to address rising resistance challenges.
  • Rajgir: Located in Nalanda district of Bihar.

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World’s First Genome-Edited Rice Varieties

GS-III : S&T Developments & their Applications & Effects in Everyday Life Bio-Technology

World’s First Genome-Edited Rice Varieties

On 5th May 2025, ICAR announced the release of two genome-edited rice varieties — ‘Kamala’ and ‘Pusa DST Rice 1’ — marking a major milestone in agricultural biotechnology.

The development highlights the growing role of genome editing in improving crop productivity, stress tolerance, and climate resilience.

Key Details
Aspect Details
Announcement ICAR announced the release on 5th May 2025.
Genome-Edited Varieties The two released varieties are ‘Kamala’ and ‘Pusa DST Rice 1’.
Sector Agricultural biotechnology and crop improvement.
Regulatory Context India’s Environment (Protection) Act, 1986 mandates regulation for GM crops, but not genome-edited crops made through SDN-1 or SDN-2 technologies.
Why This Matters
  • Marks a major step in India’s use of genome editing for crop development.
  • Supports climate-resilient agriculture through improved stress tolerance.
  • Can help improve yield, disease resistance, and resource-use efficiency.
  • Shows a regulatory distinction between GM crops and certain genome-edited crops.
PT Facts
  • Genome Editing: Modifies an organism’s existing DNA at targeted locations.
  • GM vs GE Crops: GM crops usually involve insertion of foreign genetic material, while many genome-edited crops may not.
  • SDN-1 & SDN-2: These edits generally do not involve foreign DNA insertion.
  • Crop Improvement: Genome-edited crops can improve yield, stress tolerance, disease resistance, and climate resilience.

Source:

Scientists Discover Key to Delaying Female Fertility Decline

GS-III : S&T Developments & their Applications & Effects in Everyday Life Bio-Technology

Scientists Discover Key to Delaying Female Fertility Decline

In a groundbreaking study, scientists from the National Institute of Animal Biotechnology (NIAB) found a promising way to slow down ovarian aging, the natural decline in the number and quality of egg cells, or oocytes, in females.

What the NIAB Study Found
Finding Details
Key Protein The study found that a protein called Cathepsin B (Cat B) plays a key role in speeding up ovarian aging.
Function of Cat B Cat B is an enzyme that breaks down other proteins in the body.
Main Outcome Reducing Cat B activity helped preserve the ovarian reserve and slowed down the loss of egg cells.
PT Facts
  • Oocytes: Immature egg cells involved in female reproduction.
  • Ovarian Reserve: Refers to the number and quality of eggs remaining in the ovaries.
  • Cathepsin B: A protein-degrading enzyme linked with cellular ageing processes.
  • NIAB: An autonomous institute under the Department of Biotechnology.

Source:

India’s First Polar Research Vessel

GS-III : S&T Developments & their Applications & Effects in Everyday Life Ocean Research

India’s First Polar Research Vessel

Garden Reach Shipbuilders & Engineers (GRSE) and Norway’s Kongsberg Oslo have signed a MoU for marking India’s first indigenous Polar Research Vessel (PRV).

The vessel will be constructed in Kolkata under the guidance and design expertise of Kongsberg and the shipbuilding capabilities of GRSE.

Key Details of the Polar Research Vessel
Aspect Details
Project Partners GRSE and Norway’s Kongsberg Oslo.
Construction Site The vessel will be built in Kolkata.
Technical Support Kongsberg will provide design and technical guidance, while GRSE will contribute shipbuilding capabilities.
Scientific Role The vessel will serve the National Centre for Polar and Ocean Research (NCPOR) and support scientific operations in the Arctic, Antarctica, and Southern Ocean regions.
INDIA’S RESEARCH STATIONS IN ARCTIC AND ANTARCTICA
Region Indian Research Station
Antarctica India presently has two research stations in Antarctica: Maitri and Bharati.
Arctic India’s Arctic station Himadri is located at Ny Alesund, Spitsbergen Island, Norway.
PT Facts
  • NCPOR: Located in Goa and functions under the Ministry of Earth Sciences.
  • Polar Research: Important for studying climate change, sea ice, ocean circulation, and global weather systems.
  • Southern Ocean: Surrounds Antarctica and plays a major role in global climate regulation.
  • Dakshin Gangotri: India’s first Antarctic research station, now decommissioned.

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Maitri II: India’s Upcoming Antarctic Research Station

GS-III : S&T Developments & their Applications & Effects in Everyday Life Ocean Research

Maitri II: India’s Upcoming Antarctic Research Station

The Finance Ministry recently approved the establishment of Maitri II, India’s newest Antarctic research base, to be constructed in eastern Antarctica with a financial outlay of Rs. 2,000 crore over seven years.

The Goa-based National Centre for Polar and Ocean Research (NCPOR), functioning under the Ministry of Earth Sciences (MoES), will oversee the mission.

Key Details of Maitri II
Aspect Details
Project Approval Approved by the Finance Ministry with an outlay of Rs. 2,000 crore over seven years.
Location The research base will be constructed in eastern Antarctica.
Nodal Institution The mission will be overseen by the National Centre for Polar and Ocean Research (NCPOR) under the Ministry of Earth Sciences.
Research Base Status Maitri II will be India’s fourth research base in Antarctica after Dakshin Gangotri, Maitri, and Bharati.
Completion Target The station is expected to be completed by January 2029.
Green Facility It will be designed as a green research facility, powered by solar and wind energy, with upgraded infrastructure and improved living conditions.
INDIA’S ANTARCTIC RESEARCH BASES
Research Base Status / Details
Dakshin Gangotri India’s first Antarctic research base, now decommissioned.
Maitri Established in 1989; located in the Schirmacher Oasis of East Antarctica.
Bharati India’s active Antarctic research station, commissioned in 2012.
Maitri II Upcoming Antarctic research base expected to be completed by January 2029.
Future Role of Maitri I

Maitri I, located in the Schirmacher Oasis of East Antarctica, will continue to serve as India’s summer research camp once Maitri II becomes operational.

PT Facts
  • Maitri: Located in the Schirmacher Oasis in East Antarctica.
  • Bharati: India’s active Antarctic research station commissioned in 2012.
  • Antarctic Research: Helps study climate change, ice cores, atmospheric science, geology, and polar ecosystems.
  • Antarctic Treaty System: Governs activities in Antarctica and promotes peaceful scientific cooperation.

Source:

Wet Tests of Matsya-6000

GS-III : S&T Developments & their Applications & Effects in Everyday Life Ocean Research

Wet Tests of Matsya-6000

In February 2025, India successfully conducted wet tests of Matsya-6000, the country’s first manned deep-sea submersible, marking a major milestone under the Samudrayaan mission for deep-sea mineral exploration.

The tests were aimed at ensuring system reliability before its 6,000-metre deep-sea mission in 2026.

Human support and safety systems were assessed, ensuring 12-hour endurance under normal conditions and 96 hours in emergency scenarios.

FEATURES OF MATSYA-6000
Feature Details
Mission Part of India’s Samudrayaan Project under the Deep Ocean Mission.
Design & Development Developed by the National Institute of Ocean Technology (NIOT), Chennai, under the Ministry of Earth Sciences.
Capacity Accommodates three humans inside a 2.1-meter diameter spherical hull.
Testing Phases Successfully completed dry tests at Katpalli Port, Tamil Nadu.
Testing and Safety Significance
Area Importance
Wet Tests Marked a major milestone before the planned 6,000-metre deep-sea mission.
System Reliability The tests were conducted to check reliability before deep-sea deployment in 2026.
Normal Endurance Human support systems ensure 12-hour endurance under normal conditions.
Emergency Support Safety systems provide up to 96 hours of support in emergency scenarios.
PT Facts
  • Matsya-6000: India’s manned deep-sea submersible designed for 6,000-metre depth.
  • Samudrayaan: Part of India’s Deep Ocean Mission.
  • NIOT: National Institute of Ocean Technology, located in Chennai.
  • Deep Ocean Mission: Supports exploration of deep-sea minerals, biodiversity, and ocean resources.

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Skin Diseases: A Global Public Health Priority

GS-III : S&T Developments & their Applications & Effects in Everyday Life Health

Skin Diseases: A Global Public Health Priority

On 24th May 2025, the 78th World Health Assembly (WHA) unanimously adopted a historic resolution titled “Skin diseases as a global public health priority”, the first resolution of its kind.

Skin diseases affect nearly 1.9 billion people worldwide, yet the sector remains significantly underfunded.

Low- and middle-income countries (LMICs) suffer the most from neglected skin diseases and limited access to proper dermatological care.

Key Features of the Resolution
Aspect Details
Resolution Adopted Skin diseases as a global public health priority” adopted by the 78th World Health Assembly.
Adoption Date The resolution was adopted on 24th May 2025.
Global Burden Skin diseases affect around 1.9 billion people globally.
Most Affected Regions Low- and middle-income countries (LMICs) face the highest burden of neglected skin diseases.
Public Health Significance The resolution formally places skin health within the global public health agenda.
Common Challenges Linked to Skin Diseases
Issue Impact
Underfunding Despite large disease burden, skin diseases remain inadequately funded globally.
Stigma Conditions such as psoriasis, fungal infections, and vitiligo often lead to social stigma and discrimination.
Delayed Treatment Many skin diseases remain under-treated because of poor awareness and limited access to specialists.
Healthcare Gaps in LMICs LMICs often face weaker screening systems, limited dermatology access, and a higher neglected disease burden.
PT Facts
  • World Health Assembly (WHA): Decision-making body of the World Health Organization (WHO).
  • Medical & Social Burden: Skin diseases create both healthcare and social challenges due to stigma and delayed treatment.
  • LMICs: Often face limited dermatology access, weaker screening systems, and higher neglected disease burden.
  • Global Health Agenda: The resolution pushes skin health into the international public health framework.

Source:

WHO Declares Hepatitis D as Carcinogenic

GS-III : S&T Developments & their Applications & Effects in Everyday Life Health

WHO Declares Hepatitis D as Carcinogenic

In July 2025, the World Health Organization’s International Agency for Research on Cancer (WHO-IARC) classified the hepatitis D virus (HDV) as carcinogenic to humans, highlighting its strong link to liver cancer and urging increased screening and access to treatments.

What is Hepatitis D?
Aspect Details
Disease Type A liver infection caused by the hepatitis delta virus (HDV).
Dependence on HBV HDV cannot exist on its own; it requires the hepatitis B virus (HBV) to replicate.
Key Significance of the IARC Classification
Area Importance
Carcinogenic Status WHO-IARC classified hepatitis D virus as carcinogenic to humans.
Cancer Link The classification highlights the strong link between HDV infection and liver cancer.
Public Health Action The announcement urges increased screening and better access to treatments.
PT Facts
  • HDV: Considered a satellite virus because it depends on HBV for replication.
  • HBV-HDV Infection: Co-infection or superinfection with HBV and HDV can increase the risk of severe liver disease.
  • IARC: Cancer research agency of the World Health Organization.
  • Hepatitis B Vaccine: Can indirectly help prevent hepatitis D infection.

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New Drug Candidate to Tackle Deadly Superbugs

GS-III : S&T Developments & their Applications & Effects in Everyday Life Health

New Drug Candidate to Tackle Deadly Superbugs

In August 2025, researchers at the Indian Institute of Technology (IIT) Roorkee announced the development of a new drug candidate that could restore the effectiveness of critical antibiotics against one of the world’s most dangerous superbugs.

The therapy is designed to combat infections caused by Klebsiella pneumoniae, a top-priority drug-resistant pathogen identified by the World Health Organization (WHO).

The Novel Molecule
Feature Details
Molecule Name The research team developed a novel molecule called Compound 3b.
Combination Therapy It works in combination with Meropenem, a last-resort antibiotic.
Target Pathogen The therapy targets infections caused by Klebsiella pneumoniae.
WHO Classification WHO identifies Klebsiella pneumoniae as a top-priority drug-resistant pathogen.
How does Compound 3b Work?
Mechanism / Test Observation
Enzyme Blocking Compound 3b blocks bacterial enzymes that normally destroy antibiotics.
Specificity Preclinical tests showed the molecule is highly specific in its action.
Safety The therapy was found to be safe for human cells.
Animal Model Results Tests demonstrated effectiveness in reducing lung infections in animal models.
PT Facts
  • Klebsiella pneumoniae: A major hospital-associated pathogen linked with pneumonia, bloodstream infections, and antimicrobial resistance.
  • Meropenem: Belongs to the carbapenem class of antibiotics and is often used as a last-resort treatment.
  • Superbugs: Drug-resistant bacteria are commonly referred to as superbugs.
  • AMR Strategy: Restoring antibiotic effectiveness is a key strategy against antimicrobial resistance (AMR).

Source:

9th Asian Winter Games

GS-I : World Sports Atheletics

9th Asian Winter Games

Aspect Details
Host City/Country Harbin, China.
Mascots Binbin and Nini — tiger mascots.
Table Topper China topped the medal tally with 85 medals — 32 gold, 27 silver and 26 bronze.
Second Position Republic of Korea finished second with 45 medals — 16 gold, 15 silver and 14 bronze.
India at the Event India sent its largest-ever contingent of 59 athletes but could not win any medals.
PT Facts
  • Venue: The 9th Asian Winter Games were held in Harbin, China.
  • Mascots: Binbin and Nini were the official mascots.
  • China: China topped the medal tally with 85 medals.

Source:

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23 April,2026
Expiry of New START Treaty

Expiry of New START Treaty The New START Treaty, the last major nuclear arms control agreement between the United States and Russia, expired on 5th February 2026. Its expiry ended binding limits on their strategic nuclear arsenals and raised global concerns about a renewed arms race.

Global Pandemic Treaty

Global Pandemic Treaty The WHO Pandemic Agreement was adopted by the World Health Assembly on 20 May 2025. It is a legally binding treaty aimed at improving global pandemic preparedness and response. Key Elements of the Draft Agreement Element Details

Convention on Cluster Munitions

Convention on Cluster Munitions On 6th March 2025, Lithuania officially exited the Convention on Cluster Munitions, citing national security concerns. It became the first country to leave the convention and the first EU/NATO member to exit a multilateral arms-control agreement. Wh

INF Treaty

INF Treaty On 4th August 2025, Russia formally declared that it would no longer observe the Intermediate-Range Nuclear Forces (INF) Treaty. Russia cited the deployment of U.S. intermediate-range missiles in Europe and the Asia-Pacific as a direct security threat. What was the INF

Ottawa Treaty on Landmines

Ottawa Treaty on Landmines On 19th June 2025, Finland’s Parliament approved its withdrawal from the Ottawa Treaty, which bans anti-personnel landmines. Finland became the fifth European country to move out of the treaty framework, citing rising security concerns linked to Russia.

Axiom-4 Mission

Axiom-4 Mission On 15th July 2025, Indian astronaut Group Captain Shubhanshu Shukla and three other crew members of the Axiom-4 mission safely returned to Earth after a 20-day mission to the International Space Station (ISS). Group Captain Shukla became the first Indian to visit the ISS

Fram2 Mission

Fram2 Mission On 31st March 2025, SpaceX launched its sixth private astronaut mission, Fram2, from the Kennedy Space Centre in Cape Canaveral, Florida. It became the first human mission to orbit Earth in a polar trajectory, flying from the Arctic to the Antarctic. Aspect

SPHEREx Mission

SPHEREx Mission On 11th March 2025, NASA launched the Spectro-Photometer for the History of the Universe, Epoch of Reionization and Ices Explorer (SPHEREx). The mission was launched aboard a SpaceX Falcon 9 rocket from Vandenberg Space Force Base, California. Aspect

Lunar Trailblazer

Lunar Trailblazer On 26th February 2025, the National Aeronautics and Space Administration (NASA) launched the Lunar Trailblazer satellite aboard a SpaceX Falcon 9 rocket from the Kennedy Space Center, Florida. The mission focuses on studying the presence and movement of water on the Moo

Chandrayaan-5 (LUPEX) Mission

Chandrayaan-5 (LUPEX) Mission On 14th May 2025, the Indian Space Research Organisation (ISRO) and the Japan Aerospace Exploration Agency (JAXA) jointly commenced the preliminary design phase for Chandrayaan-5. The mission is aimed at detecting water on the lunar surface and subsurface th

22 April,2026
International Emergency Economic Powers Act (IEEPA)

International Emergency Economic Powers Act (IEEPA) On 20th February 2026, the U.S. Supreme Court struck down the U.S. President’s use of emergency powers to impose sweeping tariffs under the International Emergency Economic Powers Act (IEEPA). The ruling clarified limits on presid

Israel Withdraws from UN Human Rights Council

Israel Withdraws from UN Human Rights Council On 6th February 2025, Israel announced its withdrawal from the United Nations Human Rights Council (UNHRC), citing institutional bias against Israel. Israel accused the UNHRC of persistent bias since its inception in 2006, following repeated

Jakarta Becomes the World’s Most Populated City

Jakarta Becomes the World’s Most Populated City On 27th November 2025, the UN World Urbanisation Prospects 2025 report declared Jakarta the world’s most populated city with an estimated 42 million residents, overtaking Tokyo. The rankings reflect a revised UN methodology appl

India-UK Social Security Agreement

India-UK Social Security Agreement On 10th February 2026, India and the United Kingdom signed a Social Security Agreement in New Delhi to avoid dual social security contributions for employees on temporary overseas assignments. The agreement seeks to facilitate labour mobility while redu

India-US Interim Trade Agreement Framework

India-US Interim Trade Agreement Framework On 7th February 2026, India and the United States announced a framework for an Interim Trade Agreement to advance negotiations on a broader Bilateral Trade Agreement (BTA). The framework aims to improve market access, strengthen supply chains, a

India-UK Comprehensive Economic and Trade Agreement

India-UK Comprehensive Economic and Trade Agreement On 24th July 2025, India and the United Kingdom signed the historic Comprehensive Economic and Trade Agreement (CETA), marking a new phase in bilateral economic cooperation. The agreement combines trade liberalisation, professional mobi

Australia-Canada-India Technology and Innovation (ACITI) Partnership

Australia-Canada-India Technology and Innovation (ACITI) Partnership On 22nd November 2025, the Prime Minister of India announced the launch of the Australia-Canada-India Technology and Innovation (ACITI) Partnership. The announcement came after meetings with the Australian and Canadian

India and Brazil to Expand Trade Pact under Mercosur Bloc

India and Brazil to Expand Trade Pact under Mercosur Bloc On 16th October 2025, India and Brazil agreed to expand the scope of their existing Preferential Trade Agreement (PTA) under the Mercosur bloc. The move aims to strengthen economic cooperation and expand trade relations between In

India-New Zealand Free Trade Agreement

India-New Zealand Free Trade Agreement On 22nd December 2025, India and New Zealand concluded negotiations for a landmark Free Trade Agreement (FTA). The agreement became one of India’s fastest-concluded FTAs since negotiations began in March 2025. Key Highlights of the Agre

India-EU Free Trade Agreement

India-EU Free Trade Agreement On 27th January 2026, at the 16th India-EU Summit, India and the European Union concluded negotiations on the long-pending India-EU Free Trade Agreement (FTA). The agreement was finalised nearly two decades after negotiations first began, reflecting a major

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