×

UPSC Courses

DNA banner

DAILY NEWS ANALYSIS

GS-III :
  • 21 June, 2020

  • 5 Min Read

COVID19-Plasma therapy

Antibodies from convalescent plasma protect against COVID-19

  • A team of scientists led by Dennis R. Burton from the Scripps Research Institute has discovered that neutralising antibodies present in the blood of COVID-19 infected who have recovered offers powerful protection against novel coronavirus in animals.

Role for antibodies

  • The small animals that received high dose of antibodies did not lose weight and the amount of virus in the lungs was low compared with those that received low dose of the antibodies and the control group.
  • The study suggests a role for neutralising antibodies in prophylaxis(treatment given to prevent a disease), and potentially therapy, of COVID-19.
  • Prior to transferring and testing the ability of the antibodies to protect the animals from the virus, the researchers tested it on human cell cultures and found the antibodies to have superior ability to protect against the virus.
  • Two different antibodies in five different concentrations were tested on the small animals to evaluate dose-dependent protection.
  • The highest dose tested was 2 mg/animal and the lowest dose was 8 microgram/animal.
  • The animals were challenged with the virus 12 hours after the antibodies were transferred. Lung tissues were collected to measure viral load on day 5 post virus challenge.
  • In contrast to the antibody to receptor-binding domain(RBD) of the virus, the less potent and incompletely neutralising antibody showed no evidence of protection at any concentration compared to the control animals.

Promising study

  • The authors state that the efficacy of the antibodies in Syrian hamsters is “promising” and suggest that human studies be undertaken based on animal trial results.
  • Incidentally, the researchers also identified one antibody that can neutralise the 2002 SARS virus.
  • According to the release, the antibodies can be injected into patients in the early stage of the disease to reduce the viral load and thus protect the patient from progressing to the severe form of the disease.
  • The antibodies also may be used to provide temporary, vaccine-like protection against SARS-CoV-2 infection for healthcare workers, elderly people and others who respond poorly to traditional vaccines or are suspected of a recent exposure to the coronavirus.
  • The antibodies can then be mass-produced either as a treatment to prevent deterioration of the disease and as a preventive vaccine, as in the case of Ebola virus, the release notes.
  • More than 1,000 antibody-producing immune cells called the B cells were first isolated. These antibodies were isolated based on their ability to bind to the virus and prevent it from infecting the test cells.

Gene sequence

  • Each of the 1,000 immune B cells produced a distinct antibody against the virus. In order to mass-produce the antibody, the scientists obtained the gene sequence of each antibody.
  • They then screened each antibody and 33 antibodies that could block the virus from binding to the test cells were identified.

Source: TH


Rajasthan First State to Implement Biofuel Policy

  Rajasthan First State to Implement Biofuel Policy: (GS-II(Policies) & GS-III(Environment)) Theme: Biofuel Policy Rajasthan has become the first State in the country to implement the national policy on biofuels unveiled by the Centre in May 2018.   The desert State will lay emphasis on increasing production of oils

SEHAT Scheme for Teleconsultation

Services e-Health Assistance and Teleconsultation (SeHAT) is the tri-services teleconsultation service of the Ministry of Defense designed for all entitled personnel and their families. As part of the Government’s commitment to Digital India and e-Governance, Minister of Defense launched SeHAT on 27 May 2021. It has been a great exam

PM Poshan Scheme to replace Mid Day Meal Scheme

PM Poshan (Erstwhile Mid Day Meal) Scheme Cabinet has approved the Prime Minister POSHAN scheme or PM-POSHAN for providing one hot cooked meal in Government and Government-aided schools. The scheme will replace the existing national programme for mid-day meal in schools or Mid-day Meal Scheme (launched in 1995). It has been launched for a

National Initiative for Design Innovation (NIDI)

National Initiative for Design Innovation (NIDI) Government launched the scheme of “National Initiative for Design Innovation (NIDI)” in March, 2014. Scheme envisaged establishment of 20 Design Innovation Centres (DIC), One Open Design School (ODS) and One National Design Innovation Network (NDIN) across the country for promoti

Saffron cultivation in India

Saffron is a plant whose dried stigmas (thread-like parts of the flower) are used to make saffron spice. Saffron cultivation is believed to have been introduced in Kashmir by Central Asian immigrants around the 1st Century BCE. Pampore region, in India, commonly known as Saffron bowl of Kashmir, is the main contributor to saffron p

Students Achievement

Search By Date

Newsletter Subscription
SMS Alerts