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DAILY NEWS ANALYSIS

GS-III :
  • 15 May, 2020

  • 3 Min Read

Chitra GeneLAMP-N

Chitra GeneLAMP-N

  • The Chitra GeneLAMP-N developed by the Sree Chitra Tirunal Institute for Medical Sciences and Technology (SCTIMST), Thiruvananthapuram
  • The Chitra technology uses a method called Loop mediated isothermal amplification (LAMP).
  • The objective, like that of the gold-standard RT-PCR tests, is the same: to detect the presence of viral RNA. Both achieve this via a series of chemical transformations.
  • The LAMP method is said to be faster but is a relatively newer technology, more complicated in its design and has not been tested extensively for COVID-19 detection.

N gene test

  • Most RT-PCR kits focus on two different genes, the E (envelope) gene and the RdRP (RNA dependent RNA polymerase) gene.
  • The World Health Organization recommends a E and RdRP test, while the U.S.’s Centers for Disease Control and Prevention (CDC) requires an N gene test.
  • The N gene test is a confirmatory test and widely employed in Germany and China, among other countries.
  • However, the design of it is complicated and can be expensive.
  • The CDC protocol says three regions of the N gene must be analysed but the Chitra-model tests two to confirm the identity of the virus.

Source: TH


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