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  • 30 November, 2020

  • 8 Min Read

Clear the fog, draw up a clear vaccination policy

Clear the fog, draw up a clear vaccination policy

Herd effect of vaccination

  • Vaccines play a major role in human mastery over infectious diseases.
  • Vaccine can induce immunity only in the vaccinated individual. So, vaccination is ‘preventive medicine’.
  • When a vaccine is rolled out as a national or global programme and increasing proportions of people are vaccinated, ‘herd immunity’ level increases and disease frequency decreases in the vaccinated population.
  • That decelerates transmission of the microbe in the whole community, resulting in decreasing disease frequency even in the unvaccinated segment of population — a phenomenon called the ‘herd effect’ of vaccination.

Disease burden and control

  • Herd immunity plus herd effect reduce the overall disease burden in the community; in other words, the disease is controlled.
  • In epidemiology, the common word control has a specific meaning: ‘deliberate reduction of disease frequency to a desired level, validated with evidence’.
  • For evidence, disease frequencies must be documented both at baseline and on an ongoing basis, through systematic surveillance.
  • So, control interventions include a vaccination programme and disease surveillance.
  • The extreme form of control is ‘elimination’ of transmission of the microbe in a whole country.
    • For example, measles and rubella have been eliminated in Sri Lanka through sustained vaccination achieving high coverage.
    • Eradication is global elimination of an infectious disease.
  • In summary, the hierarchy of human mastery over infectious microbes using vaccines ranges from individual protection and community control, to elimination and eradication.
  • So far, smallpox and cattle plague have been eradicated using their respective vaccines.
  • Severe Acute Respiratory Syndrome (SARS) was eradicated in 2003 without a vaccine, using ‘non-pharmacological interventions’, or NPI, systematic case detection, contact tracing and quarantine.
  • Success was possible because virus transmission occurred only after individuals developed fever.
  • History of travel from affected countries and fever-screening identified potentially infectious persons who were quarantined for breaking transmission chains.
  • COVID-19 novel coronavirus transmission occurs from infected persons before the onset of fever and from infected but totally asymptomatic individuals.
  • So, we cannot stop transmission; but with NPI (face masks, hand hygiene and avoiding crowds), we can retard transmission.

Vaccine candidates and India

  • Three COVID-19 vaccines have claims of about 90-95% protective efficacy — BNT162b2 (Pfizer-BioNTech), mRNA-1273 (Moderna) and Sputnik-V (Gamaleya Institute).
  • Hopefully they will soon get registration for general use in their respective countries of origin.
  • Sputnik-V is under phase 2-phase 3 vaccine trials in India, by Dr. Reddy’s Laboratories.
  • Another vaccine, ChAdOx1 nCoV-19 (Oxford-AstraZeneca), manufactured under licence by Serum Institute of India as Covishield, is undergoing phase 2-phase 3 trials in India.
  • The likelihood of Sputnik-V getting registration in India is probably high, possibly before end-2020.
  • An indigenous vaccine candidate, Covaxin (Bharat Biotech), found safe and immunogenic in phase 1 and phase 2 trials, is now under phase 3 trial. If found safe and effective, it will, hopefully, get registration in the first or second quarter of 2021.

Centre-State coordination

  • In India’s national Universal Immunisation Programme (UIP), policy is defined, vaccines procured and supplied by the Union government and vaccination implemented by State governments.
  • So, policy development is the function of the central governmentStates must implement the action plan emerging from policy.
  • States have the freedom to surpass policy limits if no fund is sought.
  • There are precedents: Delhi used the Measles-Mumps-Rubella vaccine when the central government policy was only for Measles vaccine and Sikkim unilaterally used human papillomavirus vaccine to prevent cervical cancer in women.

Mixed signals

  • The Drugs Controller General of India is the clearing agency, not the ICMR.
  • On November 3, the Union Health Secretary said in a press conference: “Union Health Ministry has asked State governments to refrain from making isolated plans for vaccine distribution. The Union government has set up an expert committee on vaccine administration. States were asked to set up committees under Chief Secretaries of each State to ensure time-bound implementation of the Union government’s direction”.
  • On November 19, the Puducherry Chief Minister announced that COVID-19 vaccination will be provided free under the State Budget.
  • On November 20, the Union Health Minister identified the priority sequence for vaccination: health-care workers and ‘corona warriors’; citizens above 65 years; those between 50 and 65; those below 50 who have co-morbidities; and finally general public; workers in essential services are missed out.
  • This represents a preventive medicine approach.
  • Obviously, the government has not considered a public health goal of control or elimination.

Unanswered policy issues

  • Fortunately, the three front running vaccines for India — Sputnik V, Covishield, Covaxin — need only the standard cold chain available to the UIP, except that any new vaccine will require significant additional cold chain space.
  • All vaccines in the UIP are available in the private sector too.
  • Under the UIP, vaccines attract no user fee, but the private sector bills the beneficiary.

Way forward

  • India does not practise public health surveillance. How then can India monitor the control trajectory of COVID-19 over time?
  • The COVID-19 control plan of actions can be the nucleus for building a much-needed public health infrastructure in India.
  • The vaccination stations should be staffed with trained personnel and supervised by medical doctors.
  • The site must have a waiting area and a post-vaccination staying area to manage any untoward reaction during the first hour.
  • A computerised master list with details and mobile numbers of all vaccinated subjects needs to be maintained for the purpose of post-vaccination follow up to document rare side-effects.
  • Data management has to be meticulously planned and executed.
  • The central and State governments in general and Health Departments in particular have a mammoth task ahead of them.
  • It is a big challenge to protect the life and the health of citizens, and also a huge opportunity to eliminate the novel coronavirus from India, setting an example to the rest of the world. With will and wisdom we can, and should, accomplish this.

Source: TH


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