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DAILY NEWS ANALYSIS
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09 May, 2020
5 Min Read
Introduction
A phase-2 trial involving participants with mild to moderate coronavirus (COVID-19) illness found no detectable virus within an average seven days of starting treatment with a three-drug regimen compared with 12 days in people in the control group.
Samples tested for the virus comprised nasopharyngeal swab, posterior oropharyngeal saliva, throat swab, and stool samples.
Clinical Improvement
Clinical improvement was also significantly better in those who received the three-drug regimen. Complete alleviation of symptoms was achieved in four days in the intervention group and eight days in the control group. The average hospital stay was also significantly shorter (nine days) in participants who received the three-drug therapy than in the control group (14.5 days). The three-drug regimen was found to be safe.
The three drugs used are:
Lopinavir-ritonavir is used for treating HIV, ribavirin for treating chronic hepatitis C virus, and injectable interferon beta-1b is used by multiple sclerosis patients.
The researchers had earlier demonstrated that a combination of lopinavir–ritonavir and ribavirin significantly reduced mortality and respiratory failure in patients during the 2003 SARS outbreak.
And interferon beta-1b has previously been shown to reduce viral load and improve lung problems in animal studies of Middle East respiratory syndrome (MERS) coronavirus infection.
Source: TH
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LeadIT 2.0: Leadership Group for Industry Transition UPSC GS-2 IR GS-3 S&T LeadIT 2.0 is the second phase of the India-Sweden-led global initiative to support low-carbon transition in hard-to-abate industrial sectors. Why in News? The second phase of LeadIT was announced at the LeadIT Summit 2023, ho
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India-EFTA Trade and Economic Partnership Agreement UPSC GS-2 IR/PSIR The India-EFTA TEPA is a comprehensive trade pact between India and four non-EU European countries — Iceland, Liechtenstein, Norway and Switzerland — aimed at boosting trade, investment, jobs, services, technology and supply-chain resilience. Wh
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